Skip to main content Skip to main navigation menu Skip to site footer. Abstract Searching for a way to read, think, research, and write with complex theory, the authors of this book review came together for a peer-led doctoral reading group. Given our disparate disciplinary commitments, as well as our uncertainty as to how to embark on such a task, our group coalesced around the approach offered by Alecia Y.
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Compte rendu en anglais. The abstracts of the talks are reproduced below in the order of their presentation at the workshop. Arnold Kriegstein UC San Francisco, CA, USA presented his analysis of some of the cellular and molecular aspects of the development characterizing primates and in particular human cortex. He focused on his discovery of outer radial glial oRG cells which are neural progenitors participating to the expansion of the number of neurons populating superficial layers of the cortex in human.
He also reported some new efforts to perform single cell RNA sequencing in order to analyze the diversity of cell types within progenitors of the human cortex. His work identified novel genes and unique signaling pathways expressed in various sub-populations of neural progenitors, migrating and differentiating neurons as well as non-neuronal cell types in the developing human brain.
Ed Lein Allen Brain Institute, Seattle, USA presented some new results from a large scale study of neuronal diversity characterizing developing human cortical neurons using an array of approaches including multiplexed patch clamp recording and single cell RNA sequencing. His work reveals novel neuronal subtypes defined by their functional properties, their connectivity or at least their morphology and their gene expression profiles.
This large-scale approaches will lead to new insights into what is unique about cortical circuits characterizing the human brain. Colette Dehay INSERM, Lyon discussed the spatiotemporal regulation of the cell cycle in the neocortex how corticogenesis dynamics differs between primates and rodents.